Journal article
The 2021 WHO catalogue of Mycobacterium tuberculosis complex mutations associated with drug resistance: a genotypic analysis
TM Walker, P Miotto, CU Köser, PW Fowler, J Knaggs, Z Iqbal, M Hunt, L Chindelevitch, MR Farhat, DM Cirillo, I Comas, J Posey, SV Omar, TEA Peto, A Suresh, S Uplekar, S Laurent, RE Colman, CM Nathanson, M Zignol Show all
Lancet Microbe | ELSEVIER | Published : 2022
Open access
Abstract
Background: Molecular diagnostics are considered the most promising route to achievement of rapid, universal drug susceptibility testing for Mycobacterium tuberculosis complex (MTBC). We aimed to generate a WHO-endorsed catalogue of mutations to serve as a global standard for interpreting molecular information for drug resistance prediction. Methods: In this systematic analysis, we used a candidate gene approach to identify mutations associated with resistance or consistent with susceptibility for 13 WHO-endorsed antituberculosis drugs. We collected existing worldwide MTBC whole-genome sequencing data and phenotypic data from academic groups and consortia, reference laboratories, public heal..
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Awarded by National Institutes of Health
Funding Acknowledgements
This work was supported by the Wellcome Trust/Newton Fund-Medical Research Council Collaborative Award (200205/Z/15/Z), Bill & Melinda Gates Foundation Trust (OPP1133541), and supported by a grant from Unitaid. This research was funded, in part, by the Wellcome Trust (200205/Z/15/Z). For the purpose of open access, the author has applied a CC BY public copyright licence to any Author Accepted Manuscript version arising from this submission. A complete funding statement can be found in appendix 1. We would like to thank Marcel Behr, Joconiah Chirenda, Tom Connor, Marcelo Cordeiro dos Santos, Lauren Cowan, Julio Croda, Chhavarath Dary, James Dawson, Bouke de Jong, Han de Neeling, Keertan Dheda, Tatiana Dutra, Konstantin Edokimov, David Englethaler, Neel Gandhi, Amy Gaskin, Solomon Ghebremichael, Li-Yang Hsu, Faisal Masood Khanzada, HeeJin Kim, Afranio Kritski, Connie Lam, Maria Lucia Rossetti, Flora Martinez, Elena Martinez, Neil Martinson, Barun Mathema, Vidya Mave, Anju Kagal, Neeta Pradham, Jonathan Golub, Amita Gupta, Conor Meehan, Isabela Neves de Almeida, Anna P Ralph, Alamdar Hussain Rizvi, Moises Palaci, Eddy Qing-Hao Miow, Alex Rosenthal, Richard Salvato, Giri Shan Rajahram, Elisangela Silva, Mel Spigelman, Silvana Spindola de Miranda, Grant Theron, Juan Carlos Toro, and Oren Tzfadia for efforts to contribute data and other support.